background and purpose : there has been no report in which preoperative evaluation of adc for prediction of post therapeutic outcome was presented. the aim of our study was to retrospectively evaluation the use of the apparent diffusion coefficient (adc) for the prediction of malignancy and the outcome of malignant astrocytic tumors. methods: we reviewed mri of 26 male and 14 female patients wi...

Background & Objective: Glioblastoma-multiforme is the high grade form of astrocytic tumors with a short survival time, which are the most common type of brain tumors. Therefore, finding new therapeutic options is essential. Cyclin D1 is expressed in some human malignancies and can be a potential target for therapeutic intervention. The aim of the present study was to determine...

background diffusion-weighted imaging (dwi) is a form of magnetic resonance imaging (mri) based on measuring the random brownian motion of water molecules within the biological tissues and is particularly useful in tumor characterization. objectives the purpose of this study was to evaluate the diagnostic value of dw mri and the apparent diffusion coefficient (adc) for preoperative grading of a...

Pleomorphic xanthoastrocytomas (PXAs) are rare neoplasms comprising less than 1% of all astrocytic tumors, World Health Organization (WHO) grade II glial tumour.

abstract objective tumors of the central nervous system constitute the largest group of solid neoplasms in children and are second only to leukemia in their overall frequency during childhood. the main purpose of the present study is to determine the incidence, age, sex, location and histological diagnosis of cns tumors in children, less than 15 years of age, in the mofid children's hospital, i...

Recurrence and progression to higher grade lesions are key biological events and characteristic behaviors in the evolution process of glioma. Malignant astrocytic tumors such as glioblastoma (GBM) are the most lethal intracranial tumors. However, the clinical practicability and significance of molecular parameters for the diagnostic and prognostic prediction of astrocytic tumors is still limite...

Astrocytic tumors are the most common primary brain tumors in adults. ATRX mutations have been identified in gliomas and are correlated with its loss of expression, which causes alternative lengthening of telomeres (ALT) leading to genomic instability. In this study, we aimed to explore the role of ATRX mRNA expression alteration in the progression and subclassification of astrocytic tumors and...

Loss of ATRX leads to epigenetic alterations, including abnormal levels of DNA methylation at repetitive elements such as telomeres in murine cells. We conducted an extensive DNA methylation and mRNA expression profile study on a cohort of 82 patients with astrocytic tumors to study whether ATRX expression was associated with DNA methylation level in astrocytic tumors and in which cellular func...

Astrocytic tumors are the most common form of primary brain tumor. Astrocytic tumor cells infiltrate the surrounding CNS tissue, allowing them to evade removal upon surgical resection of the primary tumor. Dynamic changes to the actin cytoskeleton are crucial to cancer cell invasion, but the specific mechanisms that underlie the particularly invasive phenotype of astrocytic tumor cells are uncl...